The northbound carriageway of the M6 between junctions 32 at Broughton and 33 at Lancaster has now reopened, although traffic in the area is still heavy.
There is still heavy traffic in north Preston and along the A6, which was the diversion route from the motorway.
Stagecoach has warned passengers on its 40, 41 and 42 services to expect delays.
Fire crews from Lancaster, Preston and Fulwood were called just after 3am today. A car had crashed and was blocking the third lane. Lancashire road police described the incident as 'serious'.
The vehicle crashed into the central reservation, and one person was been taken to hospital by ambulance.
Motorway police, Highways England and crash investigators were on the scene and debris was cleared from the carriageway.
The motorway was closed for approximately five and a half hours.