Footage has been posted on social media showing a large group of rival fans at a bridge near Wigan’s DW Stadium on Saturday afternoon.
One clip shows uniformed police officers in the middle of the fans and people walking away rubbing their eyes.
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Another video appears to show an angry man shouting at police officers before being hit on the leg with a baton.
A Greater Manchester Police spokesman said: “We are aware of a video showing our officers responding to some disorder between fans after the Wigan Athletic game against Preston North End.
"This clip is a snapshot of events and shows trained officers using tactics to manage a challenging situation.
"It is too early to know the full context at this time and – as with any event – it will be part of our wider debrief of the day’s operation.”