The raid took place in the Deepdale area of the city at around 5am yesterday morning (January 30).
Preston Police they found a 'substantial' amount of money at the property and a 22-year-old man was arrested on suspicion of money laundering.
A dramatic picture of the front door on the house that was raided was put on Preston Police's Twitter page showing it sliced in half.
A spokesman for Preston Police said on Twitter: "Yesterday at 5am, Preston NPT Task Force carried out another misuse of drugs act warrant in the Deepdale area.
"A 22-year-old male has been arrested on suspicion of money laundering after a substantial amount of cash was found."
Preston Police was contacted for further comment.