The 32-year-old man, riding a Yamaha motorbike, was injured after being involved in a collision close to the Red Scar Industrial Estate in Preston.
The man, from the Ribbleton area, suffered broken ribs and back injuries and was taken to hospital for treatment.
Longridge Road was closed for four hours while accident investigators attended the scene.
Police are appealing for information and urging any witnesses to come forward.
Lewis Turner inquest: moped rider "travelling at motorway speeds" on residential New Longton road and without fastened helmet before fatal crash
M65 motorway crews strimming verges until 4am keep residents awake at night
Police urgently need to speak to "dangerous" Karl Bruney regarding a Ribbleton firearms incident last week
Real Housewives of Cheshire: former star of hit TV show set to visit Chorley boutique
Preston Brick Veil Mosque inquiry closes as debate rages over whether the place of worship should be permitted
Sgt Tracey Ward, of Lancashire Police’s Roads Policing Unit, said: “We are continuing to investigate a collision in Ribbleton.
“We are particularly keen to speak to anyone who witnessed the incident.
“If you saw what happened, please contact us.”
Anyone with information can contact police on 101 quoting log reference 1600 of August 3.