Organisers are looking for a wide variety of musical acts, including bands and solo artists, covering all music genres.
They also want performers such as comedians, dancers, magicians and ventriloquists.
Chorley Live will take place on Friday and Saturday October 7&8.
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Coun Peter Wilson, Deputy Leader of Chorley Council, said: “We’re really looking forward to hosting Chorley Live again this year after a three-year break due to the pandemic.
“The event is a real boost to the trade among pubs, clubs and restaurants and we hope that once again it will bring more people into the town centre and show that people can have a great night out in Chorley, without having to spend a lot of money or travel to other towns and cities.
“We want to include a wide variety of performers and it will be important that we have a lot of local acts taking part so they can showcase their talent.
"I’d urge anyone interested in finding out more to get in touch with us.
“Along with performers for the main Chorley Live event, we are looking for venues who would like to take part this year.”
Nigel Stewart, from the Creative Network who will be organising the acts, said the event brings the town centre alive at night.
He said: “It’s fantastic to see how many businesses are happy to offer themselves as venues, and how it’s bringing companies together to show they are willing to get involved with the event and promote the town.
“There is a real keenness among the creative industry to get back to taking part in festivals like this and it will also be a real boost for the hospitality industry after what has been a really tough period for them.
“We’d urge people to get in touch early whether as an act or a venue as we know there will be lots of interest.”
Over 280 live performances will take place in venues over the Friday and Saturday evenings.
To enter, people will buy wristbands at £5. Children under 12 will be free, accompanied by an adult.