The A Mano restaurant will open at the site of the former Tiggis in Guildhall Street in the next two weeks.
This will be the second A Mano restaurant to open in Lancashire with the first having opened in Cathedral Walk in Blackburn last October.
For owner, Chris Maughan, the venture will be his third restaurant business and he is already well known in Preston for the Theatre Street Bar and Grill.
A spokesman for the company said: "A Mano is more than just a restaurant. It is a sanctuary for weary shoppers; a meeting place for deal makers and breakers; a destination for Preston's elite.
"It is where exceptional food and drink is complemented by unprecedented table service.
"Dining at A Mano is what you want it to be. Sit in our basement bar and enjoy a cocktail made by our talented mixologists or retreat to one of our intimate dining areas for that special occasion.
"Enjoy a full experience from salads to freshly made pasta and pizzas, with our extensive steak and seafood menu.
"A Mano's cosmopolitan menu will be sure to excite.
"Stylish dining is A Mano dining."