It tells the enduring tale of the musical icon’s rise to fame and his tragic and untimely death at the age of 22 in 1959.
In 18 short months the Texas-born Holly revolutionised contemporary music influencing everyone from The Beatles to Bruce Springsteen.
His widow, Maria Elena Holly, says of the show’s latest milestone: “When we opened the show we never imagined Buddy’s music and story would still be rocking stages and entertaining audiences around the world week-in week-out 25 years later.
Since Buddy first began there have been 24 actors playing the title role of Buddy in the West End, on tour and on Broadway . . . and throughout the world 10 couples have met and married while working in the company and there have been 20 Buddy babies!
School's out: Here's 36 scenes showing from what life was like at Archbishop Temple High School in the 90s and 00s
Years in pictures: Here's 37 pictures from 2009 showing what the people of Preston were getting up to
Love Island winner and honorary Prestonian Ekin-Su Cülcüloğlu expresses shock at win
Long lost Preston pubs: Here's 33 pictures of forgotten boozers in Preston that no longer serve pints
Picture past: Here's 29 pictures going back to 2000 and showing just what life was like in Preston
The show runs from Monday to Saturday at the Opera House.
Box office: 0844 871 3018 or www.atgtickets.com/manchester.