The Duke of Westminster is now worth £9.35bn, an increase of £790m on last year, according to The Sunday Times Rich List 2016 to be published this weekend.
Meanwhile, Preston North End owner Trevor Hemmings was in 10th place in the North West, said to be worth £725m, up £50m.
The duke’s Grosvenor Group property company reported record profits of £682m and at the end of 2014 had £5.5bn of development work in the pipeline.
In second place is Tom Morris, the man behind the Liverpool-based Home Bargains discount store chain.
Liverpool’s other big discount chain, B&M, has also been hugely rewarding for brothers Simon, Bobby and Robin Arora, who have seen their wealth rise by £170m in the past 12 months to stand at £1.92bn.
At £700m, the Blackburn-based Issa brothers have seen their wealth and the value of their Euro Garages fuel distribution group soar after a private equity group took a stake in the business last October.
The chain now has more than 341 sites around Britain, with just 25 per cent of profits coming from fuel.
They offer partnerships with retailers, including Spar and Subway at their sites.
Here are the 20 richest in the North West
1 - The Duke of Westminster - £9.35bn - Up £790m - 6
2 - Tom Morris and family - £3.05bn - Up £800m - 34
3 - John Whittaker and family - £2.34bn - Down £30m - 47
4 - Simon, Bobby and Robin Arora - £1.92bn - Up £170m - 55
5 - Fred and Peter Done - £1.3bn - Up £300m - 82=
6 - Lord Grantchester and the Moores family - £1.2bn - No change - 90=
7 - Philip Day - £1.05bn - Up £300m - 110=
8 - Peter Jones and family - £791m - Up £61m - 140
9 - Sir Paul McCartney and Nancy Shevell - £760m - Up £30m - 147=
10 - Trevor Hemmings - £725m - Up £50m - 158
11 - Mohsin and Zuber Issa - £700m - Up £550m - 164=
12 - Henry Moser and family - £600m - No change - 197=
13 - Michael Oliver and family - £580m - Down £144m - 205=
14 - The Sheppard family - £540m - Down £300m - 215=
15= - The Walker family - £530m - Up £10m - 220=
15= - The Warburton family - £530m - No change - 220=
17= - Bill Ainscough and family - £500m - Up £225m - 228=
17= - John Hargreaves and family - £500m - Down £500m - 228=
19 - Geoffrey Halstead and family - £487m - Up £137m - 240
20 - Michael Oglesby and family - £475m - Up £65m - 246=