A man had to be cut from his car after driving into a tree.
Lancashire Police and fire service attended the crash at around 6.37am on Liverpool Road in Penwortham.
A spokesman for the fire service said: "When we arrived we were asked to extricate a male from his white van.
"He had driven into a tree and the van was quite badly damaged.
"We handed him over to the ambulance crews which arrived after us."
Force incident manager for Lancashire Police, KIm Sturgess said: "The contents in the back of the van shot forward in the crash trapping the man.
"He is currently unconcious at Royal Preston Hospital."