Preston land FA Cup clash with Sheffield United
The Lilywhites make the trip to Bramall Lane on the weekend on January 27/28.
It was the last tie out of the hat in the draw made at Brighton's Amex Stadium on Monday night.
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Hide AdNorth End earned their place in the fourth round with Saturday's 5-1 victory over Wycombe, while the Blades won 1-0 at Ipswich.
The sides met at the same stage of the FA Cup three years ago.
They drew 1-1 at Deepdale before North End won 3-1 in the replay in South Yorkshire, Paul Gallagher scoring twice and Paul Huntington finding the net - it set up a fifth round tie with Manchester United.
PNE and the the Blades met in the league last month, Jordan Hugill's goal giving Preston a 1-0 win.