Ryan Ledson missed out through injury and Greg Cunningham - scorer of the first goal at Blackburn last Friday - dropped to the bench.
There were recalls for Scott Sinclair and Jayson Molumby, both of who were substitutes against Rovers.
In Ledson's absence, Molumby is expected to be next to Ben Whiteman in the sitting midfield roles.
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On the bench there was a return to the squad for Anthony Gordon, the Everton loanee having missed the win at Blackburn with a knock.
Sean Maguire missed out on the matchday squad again because of injury.
PNE: Iversen, Browne, Storey, Lindsay, Hughes, Whiteman, Molumby, Barkhuizen, Johnson, Sinclair, Evans. Subs: Ripley, van den Berg, Huntington, Rafferty, Cunningham, Gallagher, Gordon, Potts, Riis.
Watford: Bachmann, Femenia, Cathcart, Sierralta, Masina, Cleverley, Chalobah, Hughes, Sarr, Pedro, Sema. Subs: Elliott, Wilmot, Trrost-Ekong, Lazaar, Gosling, Hungbo, Gray, Zinckernagel, Perica.
Referee: Tony Harrington (Cleveland)
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