But how did the Liverpudlian make his way to Deepdale? A popular and well-travelled striker as a player, he has forged a reputation as one of the top managerial talents in the EFL at Bury and Plymouth.
Now he's tasked with getting North End heading towards the right end of the Championship after Frankie McAvoy's departure.
Here, we chart his career from fresh-faced frontman to promotion-winning boss.
Want to see fewer ads? Subscribers to the Lancashire Post get access to the ad-lite version of our website, which features 70% fewer ads and faster load times for a better experience. Find out more
1. Southport
Having been in Liverpool's youth team as a kid, Lowe would play for Southport in the early days of his career
2. Burscough
The Liverpudlian would then move onto Burscough before getting his Football League break...
3. Shrewsbury
Lowe got his chance in the pro game with Shrewsbury where he would spend five years, leaving in 2005
