The video was posted by an alarmed North End supporter and shows officers from Greater Manchester Police clashing with a group of fans who were leaving the vicinity of the DW Stadium.
The Greater Manchester Police Twitter account later posted: "We are aware of a video in circulation following the #Wigan Athletic vs. #Preston North End game at the DW stadium this afternoon. All available footage is being reviewed in line with normal procedure."
North End won the Championship game 2-1 with goals from Tom Barkhuizen and Daniel Johnson.
They were backed by 3,294 of their supporters in the away end, with the attendance being 12,439.