Gritters will be out in force tonight as the county braces for up to eight centimetres of snow.
Forecasters at The Met Office have issued a yellow “be aware” warning for snow for the region, until 12 noon on Wednesday.
Experts said it was still uncertain exactly where the snow would fall within the warning area, but places on higher ground could see up to 15cm of snow.
Lancashire County Council said their gritting crews had been treating roads across the whole county from this afternoon, and would continue into the night.
Bosses said all priority routes in Chorley, Preston, South Ribble and West Lancashire would be gritted this evening, as well as all priority routes in Lancaster, Fylde and Wyre.
They said drivers on the night shift would be patrolling and monitoring all routes across the county and treating them where necessary throughout the night, as well as refilling grit bins and replenishing salt piles where necessary.
The county council has more than 30,000 tonnes of salt in stock and 49 gritters at ten depots across the county.
Most of the snow for Preston is expected to fall overnight, with the majority falling before 4am.
Forecasters said that the yellow warning may later become an amber “be prepared” warning.