The Long Causeway was shut between Red Lees Road and Kebs Road at approximately 3.45pm on Friday (March 25).
Police said this was due to a “serious road traffic collision.”
Residents were warned the closure was likely to remain in place for a “significant period of time”.
“We would ask motorists to please avoid the area,” a spokesman for Lancashire Police added.
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The Long Causeway was shut between Red Lees Road and Kebs Road following a serious crash. (Credit: Google)