Diversions are in place as police close Preston-bound carriageway.
Emergency services were called to an RTC on the A59 at 9.14am on Monday.
Rapid response and road ambulances arrived at the scene at 9.23am where they found a car had careered off the road and flipped on to its roof.
The driver, believed to be a man in his 50s was treated by paramedics for a minor head injury.
Traffic was diverted down Cuerdale Lane while the vehicle was recovered.