Firefighters battled to free a casualty trapped in the wreckage of a car after a three vehicle pile-up during the Monday rush hour.
The smash, on the main A585 Fleetwood road, north of Kirkham, caused long tailbacks as the rescue operation was underway.
The collision happened at around 7.45am, partially blocking Fleetwood Road in both directions at Greenhalgh-with-Thistleton for more than two hours and also having a knock-on effect for traffic using Junction 3 of the M55 motorway.
Police said three cars - a Peugot 107, an Audi A4 and a Mini Cooper - collided, casuing multiple casualties.
All the injured were taken by ambulance to Blackpool Victoria Hospital where their condition is not known.