At around 7am on Sunday (September 8) Preston New Road at Samlesbury was closed in both directions due to the incident.
The closure was in place between the road and junction 31 of the M6.
It was also closed at the roundabout junction of the A59 and Preston New Road, opposite the Mercure Preston Samlesbury Hotel.
Nigel Barraclough, Force Incident Manager at Lancashire Police, said: "The incident was reported at seven this morning and closed shortly after that."
Taking to Twitter, Lancashire Police spokesman said: "We are currently dealing with a road traffic collision on Preston New Road in Samlesbury.
"The road is closed in both directions between Preston New Road and Junction 31, and the junction where the A59 and A677 meet.
"Please avoid the area. We will update you when we can."
It is currently not known how many vehicles are involved in the crash, with a police spokesman saying they "can't confirm the circumstances at this minute".
At 11am, Lancashire Road Police tweeted to say that the road will not be reopened until midday due to the "serious RTC".
By 12.10pm, the road was reopened.