The M6 near Preston is expected to be one of the worst-affected stretches of road as 25 milllion drivers get away for Easter a new report is warning.
Drivers are being warned they could face severe queues next week.
Good Friday will be the busiest day with 4.4 million journeys causing major routes to be clogged between 11am and 4.30pm, RAC research suggests.
The stretches of road likely to see the worst delays include:
++ M62 westbound from Leeds to Manchester between Junctions 27 and 18 (56-minute delay)
++ M6 northbound from Preston to Lancaster between Junctions 31 and 34 (39-minute delay)
++ M25 anticlockwise from Orpington between Junctions 4 and 30 (30-minute delay)
Highways England said it will remove more than 450 miles of roadworks in time for the Easter bank holiday, meaning 99% of motorways and major A-roads in England will be clear of cones.
RAC spokesman Rod Dennis said: "This week we're expecting a significant second wave of Easter getaway traffic, following that which we saw at the start of April when schools broke up.
"This will mean the coming week and the bank holiday will likely be characterised by lengthy queues in some spots.
"Traffic jams are frustrating at the best of times and while we can predict where some of these will crop up, it only takes a single bump or breakdown for huge tailbacks to form."
Mr Dennis urged motorists to carry out essential maintenance checks before embarking on journeys, such as tyre pressure and oil level.
Dan Croft, incident group operations manager at traffic data firm Inrix, said: "During peak hours over Easter, journeys could take UK drivers three times longer than usual.
"We are predicting Good Friday will be the worst for traffic from late morning into the afternoon.
"For drivers looking to avoid the worst congestion, the best options are to travel on Saturday, set off early in the morning and keep updated with real-time traffic data."
Rail passengers also face disruption over the bank holiday weekend as Network Rail carries out engineering work.
London Euston - the fifth busiest station in the UK - will be closed between Good Friday and Easter Monday, affecting West Coast services.
This is due to preparation work for HS2 and creating space on the concourse.
There will also be no trains at London Fenchurch Street, an amended service between Preston and Glasgow Central, and some lines through Wimbledon will be closed.
Martin Frobisher, route managing director for Network Rail's London North Western route, said: "We recognise there is never an ideal time to shut the railway for our must-do work.
"Bank holidays are the least disruptive time to do it, when fewer passengers use the railway compared to the working week. That way we can do the maximum amount of work while impacting the fewest number of people."