The collision happened at around 7.50am in lane 3 of the M6 northbound between junctions 27 (Standish, Parbold) and 28 (Leyland.
Police have closed lane 3 as they attend the scene and arrange recovery of the vehicles.
The crash and lane closure is causing significant congestion, with police managing traffic in lanes 1 and 2.
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Drivers should beware of shattered glass which is scattered across the carriageway.
Highways are expecting normal traffic conditions to return by 8.50am.
More to follow...