The M6 southbound was blocked near Bamber Bridge at junction 29 after a lorry went into the central barrier this evening.
Several other vehicles were been involved in the accident which happened just after 9pm tonight.
Highways England said: "The M6 is BLOCKED southbound between J30 and J29 due to a multi-vehicle collision involving an HGV which has crossed through the central reservation. 2 lanes (of 3) are also closed on the northbound carriageway. Minor delays on approach."
North West Motorway Police warned motorists to expect delays, saying there were lane closures in place northbound and the whole carriageway "southbound stopped at present following a single vehicle minor injury RTC that has breached the central barrier."
They said emergency services were in attendance and that "as soon as a southbound lane can be opened, we will get traffic moving again. Expect delays".
Just after 9.30pm one lane of the southbound carriageway was reopened. Police have warned motorists they may need to take extra time to complete their journeys this evening.
More to follow