Officers were called to Preston Lancaster Road (A6) close to Lancaster University around 3.15pm yesterday (Wednesday, February 17) following reports of a collision between a Volkswagen Polo and a blue Citroen.
Police believe the Polo was being driven northbound when it collided with a Citroen travelling in the opposite direction.
The driver of the Polo, a 21-year-old man, suffered extensive bruising in the incident, while a 19-year-old female passenger suffered a fractured pelvis. Both were taken to Royal Lancaster Infirmary for treatment.
The driver of the Citroen, a 68-year-old man, was taken to Royal Preston Hospital by air ambulance and treated for serious injuries to his knee and lower leg, as well as a fractured pelvis and punctured lung.
None of the injuries are thought to be life-threatening.
The road was closed for five hours while accident investigators attended.
Sgt Nigel Ralphson, of Lancashire Police, said: “We are appealing for information following a serious collision on Preston Lancaster Road.
“We would like to speak to anyone who was in the area or witnessed the incident to contact police.”
If you can help, contact police on 101 quoting log reference 0700 of February 17.