Sarah Beeny made the announcement on the Channel 4 programme of the same name on Tuesday night.
“South Ribble may not be the best known place in Britain but perhaps it deserves to be,” she said.
“I’ve been really stuck by how optimistic it is for the future and how happy people are.”
The borough beat off competition from the likes of Sheffield, Bristol and Manchester based on an analysis of national data including health, average house prices, job opportunities and road links.
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Researchers also took into account the the proportion of people aged 20- 29 in the area, income and house price to salary ratio.
Warrington was second runner up for the coveted award.