Mattel said it wants to provide a "multi-dimensional view of beauty and fashion" and "represent global diversity and inclusivity".
The company added that the doll with no hair is "reflective of hair trends seen from catwalk to the sidewalk".
"If a girl is experiencing hair loss for any reason, she can see herself reflected in the line.
The move is part of a broader effort by Mattel to make its toys more representative.
The two bestselling Barbie Fashionista dolls in the UK last year were ones with wheelchairs, according to the company.
Globally, the bestseller in the Fashionista range was a "curvy black doll with afro hair", it added.
Also being added to the range that will be launched on Tuesday is a Ken doll with "long rooted hair".
Last year, Barbie also introduced a doll with a prosthetic limb after collaborating with 13-year-old Jordan Reeves.
They will now sell a second doll with a prosthetic limb that has darker skin.
Jordan told the PA news agency: "I have always thought dolls are a really good way for kids to learn about disabilities.
"Kids have a chance to grow up learning about limb differences and amputees while they play."