Conservative former ministers and brothers Boris and Jo Johnson, on opposite ends of the Brexit debate, were among those who walked through the no lobby - joining leading eurosceptics Jacob Rees-Mogg, Mark Francois and Steve Baker.
The 10 DUP MPs - the Conservative Party's minority government allies - also rejected the deal alongside the opposition parties, including 238 Labour MPs, according to the division list.
This is how our Lancashire MPs voted:
Lancaster and Fleetwood: Cat Smith (Lab) - VOTED AGAINST
Morecambe and Lunesdale: David Morris (Con) - VOTED FOR
Ribble Valley: Nigel Evans (Con) - VOTED FOR
Wyre and Preston North: Ben Wallace (Con) - VOTED FOR
Blackpool South: Gordon Marsden (Lab) - VOTED AGAINST
Blackpool North and Cleveleys: Paul Maynard (Con) - VOTED FOR
Fylde: Mark Menzies (Con) - VOTED FOR
Preston: Mark Hendrick (Lab (Co-op)) - VOTED AGAINST
South Ribble: Seema Kennedy (Con) - VOTED FOR
Southport: Damien Moore (Con) - VOTED FOR
West Lancashire: Rosie Cooper (Lab) - VOTED AGAINST
Wigan; Lisa Nandy (Lab) - VOTED AGAINST
Chorley: Linsday Hoyle (Lab) - UNKNOWN