A CSI van is currently parked up outside McColl's in Ribbleton Avenue, where a cordon has been taped across the front of the shop.
The shop's shutters are down and a number of police officers are at the scene.
Lancashire Police has been approached for comment.
On October 28 last year, the same shop was robbed at knifepoint.
At 5.15am, two men in balaclavas threatened a member of staff before stealing cash and cigarettes.