The first KFC to open in the UK is set to leave its home on Preston’s Fishergate.
The fast-food outlet was the first outside the US and Canada, opening its doors in 1965.
But the lease on the city centre property is now for sale, and an A-board has now appeared above the shop.
Community representatives said they were saddened by the news.
Coun Drew Gale, who represents the city centre ward on Preston Council, said: “We are losing a little piece of history”.
The property, at 92-92a Fishergate, is listed online with a rent of £75,000 per year and rates of £32,535, and it is marketed for A3 restaurant use.
Coun Gale said: “I’m saddened by its closure, and hope the landlords will perhaps reassess the lease asking price or I fear it may lay empty.
“My immediate thoughts, though, are with the staff of the store.”
He added: “In my opinion, the rents and the rates are prohibitive to business growth - landlords and government need to rethink.
“They need to be more progressive in supporting current businesses and enticing new ones - that way we all benefit.”
It is not known if there are plans to relocate the restaurant elsewhere in the centre of Preston, and a company spokesman declined to comment when approached by the Evening Post.
Aidan Turner-Bishop, chairman of the Preston and South Ribble civic trust, described the news as a “symbol for social change”.
He said: “Nowadays there are lots of fast food places and this was one of the first ones in Britain.
“It was a change, in those days housewives did the cooking, and it was switching away from that towards television dinners and fast food.”