They made it seven in midweek as they beat Roterham United but made three changes going into the game in Yorkshire.
Middlesbrough are a much different test for PNE, at the other end of the Championship table, and the Lilywhites will have to get a result without a few regulars.
One notable absence is Emil Riis who suffered a season ending ACL injury at the turn of the year, the Dane a summer transfer target when Chris Wilder was Boro boss.
Ali McCann is also a long term absentee, with Liam Lindsay also unlikely to make the game due to a hamstring injury. Although Ched Evans came off injured in the last game, he could well be fit to play at the weekend.
1. An interesting celebration...
Preston North End's Brad Potts celebrates with the fans at the end of the match against Rotherham Photo: CameraSport - Lee Parker
2. GK: Freddie Woodman
The simplest decision especially going off his current form, Freddie Woodman has been excellent in recent weeks and should keep his spot. Photo: CameraSport - Lee Parker
3. CB: Jordan Storey
Jordan Storey has been one of the most consistent players for PNE this season and has been a fixture on the right side of the defence, that shouldn't change this weekend. Photo: Nigel French
4. CB: Bambo Diaby
Bambo Diaby has been colossal at the back for PNE over the last few games and he's reaping the rewards of an extended run in the side. He's come out on top against some of the best and trickiest strikers in the league, can he do it again against the Championship's top scorer? Photo: Nigel French