Highway bosses will suspend most roadworks to ease delays over the Bank Holiday but train travellers face disruption on one of Lancashire's main rail routes.
Two-thirds of roadworks will be completed or lifted in time for Bank Holiday Monday to help motorists.
A total of 18 sets of roadworks will be completed and a further 49 will be suspended between 6am on Friday, August 22 and midnight on Monday, August 25.
Work on schemes at 33 sites will not start until after the bank holiday, but roadworks at 38 locations will remain in place for safety reasons.
Roads around Lancashire are expected to be busy with visitors travelling to events, including the Southport Flower Show and the Great Eccleston Tractor Pulling Championships.
Shuttle buses will run from Southport rail station to the flower show at Victoria Park to cut traffic congestion on the M6 and A59.
Derek Turner, Highways Agency network operations director, said: "There will be a lot of people taking advantage of the late August Bank Holiday so we expect the roads to the main holiday centre, ports and airports will be busy and I urge drivers to plan their journeys."
But major upgrading work on the West Coast Main Line railway will continue over the holiday, leading to delays and reduced services.
Virgin Trains will run a reduced service between Preston and London from Saturday to Monday, with passengers having to change at either Coventry or Birmingham because of railworks.
Buses will continue to replace train services between Preston and Chorley because of engineering work, expected to last until September 6.
Most Preston Bus routes will operate on a Sunday service timetable, including park-and-rides.
Service numbers 7 to Brookfield via Withy Trees and 22 to Royal Preston Hospital via Plungington Road will not operate.
A Sunday service will also run on all Stagecoach and Fishwick buses in Lancashire.
However, a possible baggage strike at Manchester Airport has been cancelled.
Forecasters say Preston will have a mixed weekend, cloudy on Saturday but sunny on Monday.
No rain is forecast in the Preston area this weekend, despite Britain being on course for the wettest August since 1912.
Some parts of the country are expected to see more than double the average rainfall for the month.
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