With a mixed start to the season, Preston were looking to secure points as well as a positive performance on home turf against Durham University.
But they ended up on the wrong end of a 4-2 scoreline.
In front of a large West Cliff crowd the game started brightly, and the home side took early control of the game.
Some energetic midfield play from Sam Sinclair, Adam Wilson and Lopez opened up the Durham midfield and exposed their back four from the outset.
Lopez came close to opening the scoring when he broke free but the Durham keeper smothered the flick at goal.
In the 23rd minute, Preston earned themselves a penalty corner through Dave Greenough.
And he opened the scoring through a well-worked routine into the bottom corner.
But Preston’s lead was short-lived, as Samad Suleman pounced on some slack defending to squeeze the ball under debutant keeper Nathan Redman.
Despite some very positive play from both sides the score remained deadlocked until half-time.
Head coach Peter Nicholson stressed the need to remain composed and on the front foot going into the second phase of play.
However, it was Durham who showed the greater urgency.
Within a minute Preston right-half Ben Scott needed all his technical skill to take the ball clear off the line from an imposing Durham attack.
But 13 minutes into the second period, former Preston forward Harry Jackson put the students in front with a simple tap-in.
Preston were to respond immediately, when Lopez out fought a Durham midfielder, slipped the ball to David Sullivan at the top of the D, who calmly slapped the ball to Alex Thompson and he turned the ball home.
The game was now end to end and short-corners were shared evenly.
But it was Durham who capitalised on 53 minutes through a well converted drag-flick from Rory Patterson.
Preston endeavoured to find an equaliser but the ball did not fall kindly.
Durham added a last goal after the final whistle from a short-corner, which was converter by Charlie Stubbings.
Nicholson was pleased with the performance, if not the final result.
Next up is a trip to last year’s league winners Bowdon.
l After two tough weeks, Longridge Ladies bounced back with a great 9-0 win over Ulverston Ladies.
Longridge travelled to the South Lakes with just 11 players available.
Then their day got worse as they were reduced to nine players within the next 10 minutes, two green cards for petty fouls.
But Longridge found the net four times before the interval and went on to find the net five more times in the second half.
Goals came from Nicki Wilcox, who struck a hat-trick, Jess Morris (2) Jenny Key (2) Sally Seed and Phillipa Crompton.
Player of the match was Jess Reid.