Preston North End’s first visit to Hillsborough for 20 years in September 2000 saw them put Sheffield Wednesday to the sword 3-1 thanks to a second-half comeback.
They trailed at the break to an Owen Morrison goal but put on a powerful display after the interval to bring home the three points from Yorkshire.
Two substitutions made at half-time by David Moyes had a positive effect.
He put on Iain Anderson and Steve Robinson for Steve Basham and Paul McKenna.
Anderson went on to find the net, with Robinson catching the eye in midfield.
North End had ventured over the Pennines having made a good start to life in the second tier after promotion.
They had won three, drawn three and lost just two of their opening eight league games.
Their last visit to the home of the Owls had been in 1980 and there was a big following of PNE supporters for this Roses battle.
Preston goalkeeper David Lucas had a busy first 20 minutes as the home side started the stronger.
He had to scramble across his goal to block a flicked header from Andy Booth who connected with a long throw from Ritchie Humphreys.
Lucas then had to dive at full stretch to get a glove to a shot from Terry Cooke who was making his Wednesday debut after joining on loan.
The home side went ahead in the 35th minute and in some style too.
Morrison collected possession in a deep position, weaved his way towards goal, before curling a shot from 25 yards past Lucas into the top corner.
Moyes earned his corn at half-time with the double change, which certainly had the desired effect.
Robinson, who had been North End’s first summer signing after winning promotion, saw plenty of the ball after coming on.
The Irishman tested Owls keeper Kevin Pressman with a shot from outside the box.
He gave Preston more of a presence in the engine room and the visitors drew level in the 57th minute. They won a free-kick 25 yards out, Alexander curling it over the wall and into the far top corner with pinpoint accuracy, to leave Pressman helpless.
Within 12 minutes North End had turned the game on its head by taking the lead.
Michael Appleton’s ball forward found Anderson five yards outside the box.
The Scottish winger pushed forward, held off the challenge of a defender before powering a right-footed finish into the roof of the net from the edge of the box.
North End stretched their advantage and rounded off the afternoon’s scoring with a quarter of an hour left.
They were awarded a free-kick a couple of yards to the right of the penalty box, close to the byline.
Alexander side-footed it low into the middle, Robinson helped it into the six-yard box where it struck former England defender Des Walker and bounced into the net.
The defeat for Wednesday, relegated from the Premier League four months earlier, was their fourth league loss on the bounce and left them second-bottom of the table.
For PNE, it maintained a pleasing start to their first season back at this level for 19 years.