A man missing from his home in Preston.
Martin Lucas, 51, was last seen at his home address on Fishergate Hill, Preston on Friday at around 10pm.
It is believed he has left the address during the night.
He has failed to return home and police are concerned for his welfare.
PC Phil Baxendale said: “Martin suffers from a medical condition and we know that he isn’t in possession of medication that he requires so he may come across as being anxious.
“We are becoming increasingly concerned for his welfare because of his medication, but also because he has left with no money or mobile phone.
“I would appeal to anybody that may have seen Martin since Friday or knows of his current whereabouts to contact police on 101.”
Martin may be wearing a fleece or waterproof jacket and jeans or tracksuit bottoms.
He has short light brown hair and is of medium build. He may also possibly be in possession of a rucksack.