The Crafty Ladies donated £3,540 to North West Blood Bikes (NWBB) following a year of fund-raising.
Money was raised by holding a cabaret night, raffle and a table top sale. The ladies also sold items that they had knitted and crocheted throughout the year.
A spokesman for the Crafty Ladies, who meet at Tuson House, in Penwortham, said: “We are really responsive to the brilliant work done by all of NWBB.” Warren Bolton, central area manager of NWBB, said: “This is the biggest sum by far that has been raised by such a small group. We can’t thank them enough. All donations will ensure we can provide our life saving service to the North West.”